Tasked with attacking enemy shipping, their primary weapon was the Mark 14 torpedo. Due to American naval doctrine at the time, this torpedo was rarely used, however after the Pearl Harbour event, these torpedoes were suddenly used in large numbers by the submariners.
The submariners quickly noticed that firing off large numbers of torpedoes rarely caused a successful sinking of enemy ships, and their concerns were quickly passed up the chain to those who were in command.
Both the company that developed the torpedo, and those in the upper echelon's of the navy, dismissed these concerns. They blamed the submariners for having insufficient courage, for not being close enough when firing, having poor aim, and not maintaining the torpedo correctly.
It took an actual practicing submariner to run tests that determined the problem, and always in the face of criticism from those involved in development or in the upper officer staff of the navy.
If anything, this reminds us that in vitro testing, no matter how good it is, may not accurately simulate real usage of any material or procedure. It is possible, that no matter how well we try to simulate something, that we still produce something that is a complete dud because of a factor we couldn't appreciate until after we have tried it many times in real life.
We need to re-appreciate the importance of large numbers of people using a material or method in actual real clinical practice. This after all, is the actual point of developing a new material or procedure, and if it does not work in actual large scale clinical practice, then it is no good, no matter what those of a more academic or conflict of interest bent might say.
One of the massive advantages we have nowadays is internet forums. Such arenas allow hundreds, often thousands of dentists to comment on the success or failure of a procedure in actual clinical practice. It is likely that forums will start to provide a level of clinical confidence, if they do not already, that exceeds much of the literature.
So next time two hundred dentists are arguing over which procedure works in their hands, be grateful. Don't go throwing words like 'literature' and 'evidence base' around like a naval bureau of ordnance officer trying to undermine those who are literally dying because of their mistakes.
Next why don't you read I'm Afraid All The Time. We can feel the fear and do it anyway!